Quantitative Trait Loci Identification by Estimating the Genetic Model based on the Extremal Samples.

ABSTRACT:

Background

In genetic association studies with quantitative trait loci (QTL), the association between a candidate genetic marker and the trait of interest is commonly examined by the omnibus F test or by the t-test corresponding to a given genetic model or mode of inheritance. It is known that the t-test with a correct model specification is more powerful than the F test. However, since the underlying genetic model is rarely known in practice, the use of a model-specific t-test may incur substantial power loss. Robust-efficient tests, such as the Maximin Efficiency Robust Test (MERT) and MAX3 have been proposed in the literature.

Methods

In this paper, we propose a novel two-step robust-efficient approach, namely, the genetic model selection (GMS) method for quantitative tra

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8844942 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature