Pathway-level analysis of genome-wide circadian dynamics in diverse tissues in rat and mouse.

ABSTRACT: A computational framework is developed to enable the characterization of genome-wide, multi-tissue circadian dynamics at the level of "functional groupings of genes" defined in the context of signaling, cellular/genetic processing and metabolic pathways in rat and mouse. Our aim is to identify how individual genes come together to generate orchestrated rhythmic patterns and how these may vary within and across tissues. We focus our analysis on four tissues (adipose, liver, lung, and muscle). A genome-wide pathway-centric analysis enables us to develop a comprehensive picture on how the observed circadian variation at the individual gene level, orchestrates functional responses at the pathway level. Such pathway-based "meta-data" analysis enables the rational integration and comparison acro

SUBMITTER: Acevedo A 

PROVIDER: S-EPMC8844946 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature