NK cells in treated HIV-infected children display altered phenotype and function.

ABSTRACT:

Background

Chronic HIV infection is known to trigger a population redistribution and alteration in the functional capacity of natural killer (NK) cells. Because of improved antiretroviral treatments, there are rising numbers of adolescents and young adults worldwide who are living with HIV infection since birth.

Objective

We sought to determine how NK-cell phenotypic and functional subsets are altered in treated pediatric patients.

Methods

NK cells were contrasted among 29 HIV-unexposed and uninfected controls (5-19 years), 23 HIV-exposed but uninfected patients (3-19 years), and 25 HIV-infected patients (3-19 years) using multiparametric flow cytometry.

Results

Although most NK-cell markers did not differ, activating receptors such as NKp46, DNAX accessory mol

SUBMITTER: Mahapatra S 

PROVIDER: S-EPMC8844948 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature