Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events.

ABSTRACT:

Objective

The gut microbiota plays a key role in modulating host immune response. We conducted a prospective, observational study to examine gut microbiota composition in association with immune responses and adverse events in adults who have received the inactivated vaccine (CoronaVac; Sinovac) or the mRNA vaccine (BNT162b2; BioNTech; Comirnaty).

Design

We performed shotgun metagenomic sequencing in stool samples of 138 COVID-19 vaccinees (37 CoronaVac and 101 BNT162b2 vaccinees) collected at baseline and 1 month after second dose of vaccination. Immune markers were measured by SARS-CoV-2 surrogate virus neutralisation test and spike receptor-binding domain IgG ELISA.

Results

We found a significantly lower immune response in recipients of CoronaVac than BNT162b2 vacc

SUBMITTER: Ng SC 

PROVIDER: S-EPMC8844967 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature