Association between pharmaceutical modulation of oestrogen in postmenopausal women in Sweden and death due to COVID-19: a cohort study.

ABSTRACT:

Objective

Determine whether augmentation of oestrogen in postmenopausal women decreases the risk of death following COVID-19.

Design

Nationwide registry-based study in Sweden based on registries from the Swedish Public Health Agency (all individuals who tested positive for SARS-CoV-2); Statistics Sweden (socioeconomical variables) and the National Board of Health and Welfare (causes of death).

Participants

Postmenopausal women between 50 and 80 years of age with verified COVID-19.

Interventions

Pharmaceutical modulation of oestrogen as defined by (1) women with previously diagnosed breast cancer and receiving endocrine therapy (decreased systemic oestrogen levels); (2) women receiving hormone replacement therapy (increased systemic oestrogen levels) and (3) a c

SUBMITTER: Sund M 

PROVIDER: S-EPMC8844968 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature