Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study.

ABSTRACT:

Importance

During pregnancy in women with epilepsy, lower blood concentrations of antiseizure medications can have adverse clinical consequences.

Objective

To characterize pregnancy-associated concentration changes for several antiseizure medications among women with epilepsy.

Design, setting, and participants

Enrollment in this prospective, observational cohort study, Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD), occurred from December 19, 2012, to February 11, 2016, at 20 US sites. Enrolled cohorts included pregnant women with epilepsy and nonpregnant control participants with epilepsy. Inclusion criteria were women aged 14 to 45 years, an intelligence quotient greater than 70 points, and, for the cohort of pregnant women, a fetal

SUBMITTER: Pennell PB 

PROVIDER: S-EPMC8845026 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature