Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management study

ABSTRACT: Abstract

Objective

To evaluate the safety and efficiency of a diagnostic algorithm for deep vein thrombosis (DVT) that uses clinical pretest probability based D-dimer thresholds to exclude DVT.

Design

Prospective diagnostic management study.

Setting

University based emergency departments or outpatient clinics in Canada.

Participants

Patients with symptoms or signs of DVT.

Intervention

DVT was considered excluded without further testing by Wells low clinical pretest probability and D-dimer <1000 ng/mL or Wells moderate clinical pretest probability and D-dimer <500 ng/mL. All other patients had proximal ultrasound imaging. Repeat proximal ultrasonography was restricted to patients with initially negative ultrasonography, low or moderate clinical p

SUBMITTER: Kearon C 

PROVIDER: S-EPMC8845040 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature