Toenail selenium, genetic variation in selenoenzymes and risk and outcome in glioma.

ABSTRACT:

Background

Selenium is an essential trace element obtained through diet that plays a critical role in DNA synthesis and protection from oxidative damage. Selenium intake and polymorphisms in selenoproteins have been linked to the risk of certain cancers though data for glioma are sparse.

Methods

In a case-control study of glioma, we examined the associations of selenium in toenails and genetic variants in the selenoenzyme pathway with the risk of glioma and patient survival. A total of 423 genetic variants in 29 candidate genes in the selenoenzyme pathway were studied in 1547 glioma cases and 1014 healthy controls. Genetic associations were also examined in the UK Biobank cohort comprised of 313,868 persons with 322 incident glioma cases. Toenail selenium was measured in a s

SUBMITTER: Peeri NC 

PROVIDER: S-EPMC8845067 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature