Meta-analysis of economic evaluation studies: data harmonisation and methodological issues.

ABSTRACT:

Background

In the context of ever-growing health expenditure and limited resources, economic evaluations aid in making evidence-informed policy decisions. Cost-utility analysis (CUA) is often used, and CUA data synthesis is also desirable, but methodological issues are challenged. Hence, we aim to provide a step-by-step process to prepare the CUA data for meta-analysis.

Methods

Data harmonisation methods were constructed specifically considering CUA methodology, including inconsistent reports, economic parameters, heterogeneity (i.e., country's income, time horizon, perspective, modelling approaches, currency, willingness to pay). An incremental net benefit (INB) and its variance were estimated and pooled across studies using a basic meta-analysis by COMER.

Results

Fi

SUBMITTER: Bagepally BS 

PROVIDER: S-EPMC8845252 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature