Serotoninergic receptor ligands improve Tamoxifen effectiveness on breast cancer cells.

ABSTRACT:

Background

Serotonin (or 5-Hydroxytryptamine, 5-HT) signals in mammary gland becomes dysregulated in cancer, also contributing to proliferation, metastasis, and angiogenesis. Thus, the discovery of novel compounds targeting serotonin signaling may contribute to tailor new therapeutic strategies usable in combination with endocrine therapies. We have previously synthesized serotoninergic receptor ligands (SER) with high affinity and selectivity towards 5-HT_2A and 5-HT_2C receptors, the main mediators of mitogenic effect of serotonin in breast cancer (BC). Here, we investigated the effect of 10 SER on viability of MCF7, SKBR3 and MDA-MB231 BC cells and focused on their potential ability to affect Tamoxifen responsiveness in ER⁺ cells.

Methods

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SUBMITTER: Ambrosio MR 

PROVIDER: S-EPMC8845285 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature