Degeneracy measures in biologically plausible random Boolean networks.

ABSTRACT:

Background

Degeneracy-the ability of structurally different elements to perform similar functions-is a property of many biological systems. Highly degenerate systems show resilience to perturbations and damage because the system can compensate for compromised function due to reconfiguration of the underlying network dynamics. Degeneracy thus suggests how biological systems can thrive despite changes to internal and external demands. Although degeneracy is a feature of network topologies and seems to be implicated in a wide variety of biological processes, research on degeneracy in biological networks is mostly limited to weighted networks. In this study, we test an information theoretic definition of degeneracy on random Boolean networks, frequently used to model gene regulatory ne

SUBMITTER: Kocaoglu B 

PROVIDER: S-EPMC8845291 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature