Investigation and characterization of human gut phageome in advanced liver cirrhosis of defined etiologies.

ABSTRACT:

Background

Liver cirrhosis is a major public health problem, accounting for high rates of morbidity and mortality worldwide. The cirrhosis etiology is a broad and essential step in planning a treatment strategy. Many recent studies have documented that gut microbiome alterations play a vital role in the development and progression of cirrhosis and its complications. Nevertheless, there is insufficient data on the correlation between liver cirrhosis and gut phageome alterations in patients with advanced liver diseases. This study aimed to analyze the taxonomic structure and functional attributes of the gut phageome in six different etiologies of advanced liver cirrhosis.

Methods

We first retrieved metagenomic sequencing data from three datasets of fecal samples taken from cir

SUBMITTER: Naseri M 

PROVIDER: S-EPMC8845349 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature