MutationalPatterns: the one stop shop for the analysis of mutational processes.

ABSTRACT:

Background

The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. These processes can be investigated by extracting relevant mutational patterns from sequencing data.

Results

Here, we present the next version of MutationalPatterns, an R/Bioconductor package, which allows in-depth mutational analysis of catalogues of single and double base substitutions as well as small insertions and deletions. Major features of the package include the possibility to perform regional mutation spectra analyses and the possibility to detect strand asymmetry phenomena, such as lesion segregation. On top of this, the package also contains functions to determine how likely it is that a signature can cause damaging mutations

SUBMITTER: Manders F 

PROVIDER: S-EPMC8845394 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature