Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis.

ABSTRACT:

Background

Higher circulating polyunsaturated fatty acids (PUFAs), especially omega-3 ones, have been linked to a better prognosis in patients of coronavirus disease 2019 (COVID-19). However, the effects and causality of pre-infection PUFA levels remain unclear.

Objective

To investigate the observational and causal associations of circulating PUFAs with COVID-19 susceptibility and severity.

Design

We first performed a prospective cohort study in UK Biobank, with 20,626 controls who were tested negative and 4,101 COVID-19 patients, including 970 hospitalized ones. Plasma PUFAs at baseline were measured by nuclear magnetic resonance, including total PUFAs, omega-3 PUFAs, omega-6 PUFAs, docosahexaenoic acid (DHA), linoleic acid (LA), and the omega-6/omega-3 ratio. Moreov

SUBMITTER: Sun Y 

PROVIDER: S-EPMC8845430 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature