Antibody and memory B-cell immunity in a heterogeneously SARS-CoV-2 infected and vaccinated population.

ABSTRACT: Global population immunity to SARS-CoV-2 is accumulating through heterogenous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied B-cell immunity in Mexico, a middle-income country where five different vaccines have been deployed to populations with high SARS-CoV-2 incidence. Levels of antibodies that bound a stabilized prefusion spike trimer, neutralizing antibody titers and memory B-cell expansion correlated with each other across vaccine platforms. Nevertheless, the vaccines elicited variable levels of B-cell immunity, and the majority of recipients had undetectable neutralizing activity against the recently emergent omicron variant. SARS-CoV-2 infection, experienced pr

SUBMITTER: Bednarski E 

PROVIDER: S-EPMC8845433 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature