Factors associated with use of immunohistochemical markers in the histopathological diagnosis of cutaneous melanocytic lesions.

ABSTRACT:

Background

Melanocytic tumors are often challenging and constitute almost one in four skin biopsies. Immunohistochemical (IHC) studies may assist diagnosis; however, indications for their use are not standardized.

Methods

A test set of 240 skin biopsies of melanocytic tumors was examined by 187 pathologists from 10 US states, interpreting 48 cases in Phase I and either 36 or 48 cases in Phase II. Participant and diagnosis characteristics were compared between those who reported they would have ordered, or who would have not ordered IHC on individual cases. Intraobserver analysis examined consistency in the intent to order when pathologists interpreted the same cases on two occasions.

Results

Of 187 participants interpreting 48 cases each, 21 (11%) did not request IHC

SUBMITTER: May CJ 

PROVIDER: S-EPMC8845493 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature