Phenotypic and Genomic Diversification in Complex Carbohydrate-Degrading Human Gut Bacteria.

ABSTRACT: Symbiotic bacteria are responsible for the majority of complex carbohydrate digestion in the human colon. Since the identities and amounts of dietary polysaccharides directly impact the gut microbiota, determining which microorganisms consume specific nutrients is central for defining the relationship between diet and gut microbial ecology. Using a custom phenotyping array, we determined carbohydrate utilization profiles for 354 members of the Bacteroidetes, a dominant saccharolytic phylum. There was wide variation in the numbers and types of substrates degraded by individual bacteria, but phenotype-based clustering grouped members of the same species indicating that each species performs characteristic roles. The ability to utilize dietary polysaccharides and endogenous mucin glyca

SUBMITTER: Pudlo NA 

PROVIDER: S-EPMC8845570 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature