Acinetobacter baumannii Regulates Its Stress Responses via the BfmRS Two-Component Regulatory System.

ABSTRACT: Acinetobacter baumannii is a common nosocomial pathogen that utilizes numerous mechanisms to aid its survival in both the environment and the host. Coordination of such mechanisms requires an intricate regulatory network. We report here that A. baumannii can directly regulate several stress-related pathways via the two-component regulatory system BfmRS. Similar to previous studies, results from transcriptomic analysis showed that mutation of the BfmR response regulator causes dysregulation of genes required for the oxidative stress response, the osmotic stress response, the misfolded protein/heat shock response, Csu pilus/fimbria production, and capsular polysaccharide biosynthesis. We also found that the BfmRS system is involved in controlling siderophore biosynthesis and transport, and t

SUBMITTER: Palethorpe S 

PROVIDER: S-EPMC8846317 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature