Associations between Gut Microbiota and Intestinal Inflammation, Permeability and Damage in Young Malawian Children.

ABSTRACT:

Background

Environmental enteric dysfunction (EED) is common in low- and middle-income countries and associated with childhood undernutrition. The composition of gut microbiota has been implicated in the pathogenesis of EED. Our aim was to assess the associations between gut microbiota and EED biomarkers in rural Malawian children. We hypothesized that there would be an inverse association between microbiota maturity and diversity and fecal concentrations of EED biomarkers.

Methods

We used data from fecal samples collected at 6, 18 and 30 months from 611 children who were followed up during a nutrition intervention trial. The primary time point for analysis was 18 months. Microbiota data were obtained through 16S rRNA sequencing and variables included microbiota maturity and

SUBMITTER: Kortekangas E 

PROVIDER: S-EPMC8846364 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature