Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer.

ABSTRACT: Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer (BC). However, the potential roles of m6A modification in the tumor microenvironment (TME) of BC remain unclear. For addressing this issue, we comprehensively analyzed the m6A modification patterns in 983 samples and correlated these modification patterns with TME immune cell infiltration, based on 23 kinds of m6A regulators. Principal component analysis (PCA) was used to construct the m6A scoring system to quantify the modification pattern of m6A of BC individuals. Consequently, three different m6A modification patterns were identified, and the infiltrating characteristics of TME cells were consistent with t

SUBMITTER: Dong M 

PROVIDER: S-EPMC8846385 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature