The seroepidemiology of dengue in a US military population based in Puerto Rico during the early phase of the Zika pandemic.

ABSTRACT: Understanding the burden and risk factors of dengue virus (DENV) infection in Puerto Rico is important for the prevention of dengue in local, traveler and military populations. Using sera from the Department of Defense Serum Repository, we estimated the prevalence and predictors of DENV seropositivity in those who had served in Puerto Rico, stratified by birth or prior residence ("birth/residence") in dengue-endemic versus non-endemic regions. We selected sera collected in early 2015 from 500 U.S. military members, a time-point also permitting detection of early cryptic Zika virus (ZIKV) circulation. 87.2% were born or resided in a DENV-endemic area before their military service in Puerto Rico. A high-throughput, flow-cytometry-based neutralization assay was employed to screen sera for ZIK

SUBMITTER: Pollett S 

PROVIDER: S-EPMC8846501 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature