In silico recognition of a prognostic signature in basal-like breast cancer patients.

ABSTRACT:

Background

Triple-negative breast cancers (TNBCs) display poor prognosis, have a high risk of tumour recurrence, and exhibit high resistance to drug treatments. Based on their gene expression profiles, the majority of TNBCs are classified as basal-like breast cancers. Currently, there are not available widely-accepted prognostic markers to predict outcomes in basal-like subtype, so the selection of new prognostic indicators for this BC phenotype represents an unmet clinical challenge.

Results

Here, we attempted to address this challenging issue by exploiting a bioinformatics pipeline able to integrate transcriptomic, genomic, epigenomic, and clinical data freely accessible from public repositories. This pipeline starts from the application of the well-established network-bas

SUBMITTER: Conte F 

PROVIDER: S-EPMC8846521 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature