Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.

ABSTRACT: The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the pathogen's ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tractable animal models do not recapitulate the heterogeneity of tuberculosis disease. We leveraged the genetically diverse Collaborative Cross (CC) mouse panel in conjunction with a library of Mtb mutants to create a resource for associating bacterial genetic requirements with host genetics and immunity. We report that CC strains vary dramatically in their susceptibility to infection and produce qualitatively distinct immune states. Global analysis of Mtb transposon mutant fitness (TnSeq) across the CC panel revealed tha

SUBMITTER: Smith CM 

PROVIDER: S-EPMC8846590 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature