Alzheimer's Disease-Related Neuropathology Among Patients with Medication Treated Type 2 Diabetes in a Community-Based Autopsy Cohort.

ABSTRACT:

Background

Diabetes is a risk factor for Alzheimer's disease and related dementias (ADRD). Epidemiologic evidence shows an association between diabetes medications and ADRD risk; cell and mouse models show diabetes medication association with AD-related neuropathologic change (ADNC).

Objective

This hypothesis-generating analysis aimed to describe autopsy-measured ADNC for individuals who used diabetes medications.

Methods

Descriptive analysis of ADNC for Adult Changes in Thought (ACT) Study autopsy cohort who used diabetes medications, including sulfonylureas, insulin, and biguanides; total N = 118. ADNC included amyloid plaque distribution (Thal phasing), neurofibrillary tangle (NFT) distribution (Braak stage), and cortical neuritic plaque density (CERAD score). We a

SUBMITTER: Barthold D 

PROVIDER: S-EPMC8846930 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature