Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype.

ABSTRACT: Tumor-associated macrophages (TAM) are an important component of the tumor microenvironment (TME) that can promote tumor progression, metastasis, and resistance to therapies. Although TAMs represent a promising target for therapeutic intervention, the complexity of the TME has made the study of TAMs challenging. Here, we established a physiologically relevant in vitro TAM polarization system that recapitulates TAM protumoral activities. This system was used to characterize dynamic changes in gene expression and protein phosphorylation during TAM polarization and to screen phenotypic kinase inhibitors that impact TAM programming. BMS-794833, a multitargeted compound, was identified as a potent inhibitor of TAM polarization. BMS-794833 decreased protumoral properties of TAMs in vit

SUBMITTER: Nishida-Aoki N 

PROVIDER: S-EPMC8847322 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature