Broadband selective excitation radiofrequency pulses for optimized localization in vivo.

ABSTRACT:

Purpose

The aim of the study is to optimize the performance of localized ¹ H MRS sequences at 3T, using the entire spin system of N-acetyl aspartate (NAA) as an example of the large chemical shift spread of all the metabolites routinely detected in vivo, including the amide region. We specifically focus on the design of the suitable broadband excitation radiofrequency (RF) pulses to minimize chemical shift artifacts.

Methods

The performance of the excitation and refocusing pulse shapes is evaluated with respect to NAA localization. Two new excitation RF pulses are developed to achieve optimized performance in the brain using single-voxel ¹ H MRS at 3T. Numerical simulations and in vivo experiments are carried out to demonstrate the performance of the RF

SUBMITTER: Kaiser LG 

PROVIDER: S-EPMC8847340 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature