Effect of substrate stiffness on friction in collective cell migration.

ABSTRACT: In collective cell migration, the motion results from forces produced by each cell and transmitted to the neighboring cells and to the substrate. Because inertia is negligible and the migration occurs over long time scales, the cell layer exhibits viscous behavior, where force and motion are connected by an apparent friction that results from the breaking and forming of adhesive bonds at the cell-cell and cell-substrate interfaces. Most theoretical models for collective migration include an apparent friction to connect force and motion, with many models making predictions that depend on the ratio of cell-cell and cell-substrate friction. However, little is known about factors that affect friction, leaving predictions of many theoretical models untested. Here, we considered how substrate st

SUBMITTER: Vazquez K 

PROVIDER: S-EPMC8847350 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature