Scalable batch fabrication of ultrathin flexible neural probes using a bioresorbable silk layer.

ABSTRACT: Flexible intracerebral probes for neural recording and electrical stimulation have been the focus of many research works to achieve better compliance with the surrounding tissue while minimizing rejection. Strategies have been explored to find the best way to insert flexible probes into the brain while maintaining their flexibility once positioned. Here, we present a novel and versatile scalable batch fabrication approach to deliver ultrathin and flexible probes consisting of a silk-parylene bilayer. The biodegradable silk layer, whose degradation time is programmable, provides a temporary and programmable stiffener to allow the insertion of ultrathin parylene-based flexible devices. Our innovative and robust batch fabrication technology allows complete freedom over probe design in terms o

SUBMITTER: Cointe C 

PROVIDER: S-EPMC8847482 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature