Pseudo contrastive labeling for predicting IVF embryo developmental potential.

ABSTRACT: In vitro fertilization is typically associated with high failure rates per transfer, leading to an acute need for the identification of embryos with high developmental potential. Current methods are tailored to specific times after fertilization, often require expert inspection, and have low predictive power. Automatic methods are challenged by ambiguous labels, clinical heterogeneity, and the inability to utilize multiple developmental points. In this work, we propose a novel method that trains a classifier conditioned on the time since fertilization. This classifier is then integrated over time and its output is used to assign soft labels to pairs of samples. The classifier obtained by training on these soft labels presents a significant improvement in accuracy, even as early as 30 h pos

SUBMITTER: Erlich I 

PROVIDER: S-EPMC8847488 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature