Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones.

ABSTRACT: Bone fractures commonly repair by forming a bridging structure called callus, which begins as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing is a promising technique for image-based assessment of structural bone healing in both preclinical and clinical settings, but its accuracy depends on the validity of the material model used to assign tissue mechanical properties. The goal of this study was to develop a constitutive model for callus that captures the heterogeneity and biomechanical duality of the callus, which contains both soft tissue and woven bone. To achieve this, a large-scale optimization analysis was performed on 2363 variations of 3D finite element models derived from computed tomography (CT) scans of 33 osteotomized sheep under n

SUBMITTER: Inglis B 

PROVIDER: S-EPMC8847550 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature