Cell specific peripheral immune responses predict survival in critical COVID-19 patients.

ABSTRACT: SARS-CoV-2 triggers a complex systemic immune response in circulating blood mononuclear cells. The relationship between immune cell activation of the peripheral compartment and survival in critical COVID-19 remains to be established. Here we use single-cell RNA sequencing and Cellular Indexing of Transcriptomes and Epitomes by sequence mapping to elucidate cell type specific transcriptional signatures that associate with and predict survival in critical COVID-19. Patients who survive infection display activation of antibody processing, early activation response, and cell cycle regulation pathways most prominent within B-, T-, and NK-cell subsets. We further leverage cell specific differential gene expression and machine learning to predict mortality using single cell transcriptomes. We ide

SUBMITTER: Amrute JM 

PROVIDER: S-EPMC8847593 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature