IFNγ-Stimulated B Cells Inhibit T Follicular Helper Cells and Protect Against Atherosclerosis.

ABSTRACT: B and T cells are interconnected in the T follicular helper-germinal center B cell (T_FH-GC B cell) axis, which is hyperactive during atherosclerosis development and loss of control along this axis results in exacerbated atherosclerosis. Inhibition of the T_FH-GC B cell axis can be achieved by providing negative co-stimulation to T_FH cells through the PD-1/PD-L1 pathway. Therefore, we investigated a novel therapeutic strategy using PD-L1-expressing B cells to inhibit atherosclerosis. We found that IFNγ-stimulated B cells significantly enhanced PD-L1 expression and limited T_FH cell development. To determine whether IFNγ-B cells can reduce collar-induced atherosclerosis, apoE ^-/- mice fed a Western-type diet were treated with PBS, B

SUBMITTER: Douna H 

PROVIDER: S-EPMC8847680 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature