Maternal plasma lipids are involved in the pathogenesis of preterm birth.

ABSTRACT:

Background

Preterm birth is defined by the onset of labor at a gestational age shorter than 37 weeks, and it can lead to premature birth and impose a threat to newborns' health. The Puerto Rico PROTECT cohort is a well-characterized prospective birth cohort that was designed to investigate environmental and social contributors to preterm birth in Puerto Rico, where preterm birth rates have been elevated in recent decades. To elucidate possible relationships between metabolites and preterm birth in this cohort, we conducted a nested case-control study to conduct untargeted metabolomic characterization of maternal plasma of 31 women who experienced preterm birth and 69 controls who underwent full-term labor at 24-28 gestational weeks.

Results

A total of 333 metabolites were id

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8847704 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature