Protein disulfide isomerase a4 promotes lung cancer development via the Stat3 pathway in stromal cells.

ABSTRACT:

Background

Protein disulfide isomerases a4 (Pdia4) is known to be involved in cancer development. Our previous publication showed that Pdia4 positively promotes cancer development via its inhibition of procaspase-dependent apoptosis in cancer cells. However, nothing is known about its role in the cancer microenvironment.

Results

Here, we first found that Pdia4 expression in lung cancer was negatively correlated with patient survival. Next, we investigated the impact of host Pdia4 in stromal cells during cancer development. We showed that Pdia4 was expressed at a low level in stromal cells, and this expression was up-regulated akin to its expression in cancer cells. This up-regulation was stimulated by tumour cell-derived stimuli. Genetics studies in tumour-bearing wild-type

SUBMITTER: Chen TY 

PROVIDER: S-EPMC8847735 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature