The representation of Indigenous peoples in chronic disease clinical trials in Australia, Canada, New Zealand, and the United States.

ABSTRACT:

Background

Indigenous peoples are overrepresented with chronic health conditions and experience suboptimal outcomes compared with non-Indigenous peoples. Genetic variations influence therapeutic responses, thus there are potential risks and harm when extrapolating evidence from the general population to Indigenous peoples. Indigenous population-specific clinical studies, and inclusion of Indigenous peoples in general population clinical trials, are perceived to be rare. Our study (1) identified and characterized Indigenous population-specific chronic disease trials and (2) identified the representation of Indigenous peoples in general population chronic disease trials conducted in Australia, Canada, New Zealand, and the United States.

Methods

For Objective 1, publicly availa

SUBMITTER: Umaefulam V 

PROVIDER: S-EPMC8847750 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature