Complementary effects of Orthosiphon stamineus standardized ethanolic extract and rosmarinic acid in combination with gemcitabine on pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer is one of the most notorious cancers and is known for its highly invasive characteristics, drug resistance, and metastatic progression. Unfortunately, many patients with advanced pancreatic cancer become insensitive towards gemcitabine treatment. Orthosiphon stamineus (O.s) is used widely as a traditional medicine for the treatment of multiple ailments, including cancer in South East Asia. The present in vitro study was designed to investigate the complementary effects of an ethanolic extract of O.s (Et. O.s) or rosmarinic acid in combination with gemcitabine on Panc-1 pancreatic cancer cells.

Method

Cell viability and colony formation assays were used to determine the 50% inhibitory concentration (IC₅₀) of Et. O.s, rosmarinic acid, an

SUBMITTER: Yehya AHS 

PROVIDER: S-EPMC8847836 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature