The positive-negative mode link between brain connectivity, demographics and behaviour: a pre-registered replication of Smith et al. (2015).

ABSTRACT: In mental health research, it has proven difficult to find measures of brain function that provide reliable indicators of mental health and well-being, including susceptibility to mental health disorders. Recently, a family of data-driven analyses have provided such reliable measures when applied to large, population-level datasets. In the current pre-registered replication study, we show that the canonical correlation analysis (CCA) methods previously developed using resting-state magnetic resonance imaging functional connectivity and subject measures (SMs) of cognition and behaviour from healthy adults are also effective in measuring well-being (a 'positive-negative axis') in an independent developmental dataset. Our replication was successful in two out of three of our pre-registered cr

SUBMITTER: Goyal N 

PROVIDER: S-EPMC8847886 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature