Characterization of Retinal Function Using Microperimetry-Derived Metrics in Both Adults and Children With RPGR-Associated Retinopathy.

ABSTRACT:

Purpose

To investigate microperimetry testing of retinitis pigmentosa GTPase regulator gene (RPGR)-associated retinopathy in a cohort of children and adults.

Design

Prospective observational case series.

Methods

The coefficient of repeatability and intraclass correlation coefficient (ICC) of mean sensitivity (MS) were calculated for mesopic microperimetry. Best-corrected visual acuity (BCVA), contrast sensitivity (CS), MS, total volume (V_TOT), and central 3-degree field volume (V₃) from volumetric and topographic analyses were acquired.

Results

The study recruited 76 individuals with RPGR (53 adults, 23 children). The mean follow-up period was 2.8 years. The ICC values for MS, V_TOT, and V₃ were 0.982 dB (95% CI, 0.969

SUBMITTER: Anikina E 

PROVIDER: S-EPMC8847997 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature