In-hospital blood collection increases the rate of indeterminate results in interferon-gamma release assays.

ABSTRACT:

Background

The interferon (IFN)-γ release assay (IGRA) has recently been established as a method to evaluate the infection status of tuberculosis instead of the tuberculin skin test. However, indeterminate results can create challenges to interpretation. The IGRA has been available in Japan since 2005, including the recently launched QuantiFERON-TB Gold Plus (QFT-plus) assay.

Objectives

The aim of this study was to investigate the clinical features and predictors of indeterminate results by the QFT-plus test in routine practice.

Methods

This was a cross-sectional study of 1258 patients. Multivariate logistic regression models were employed to investigate the clinical factors related to indeterminate results by the QFT-plus.

Results

Overall, 91.8% of results wer

SUBMITTER: Osakabe Y 

PROVIDER: S-EPMC8848041 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature