Progesterone Inhibits the Establishment of Activation-Associated Chromatin During T_H1 Differentiation.

ABSTRACT: T_H1-mediated diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) improve during pregnancy, coinciding with increasing levels of the pregnancy hormone progesterone (P4), highlighting P4 as a potential mediator of this immunomodulation. Here, we performed detailed characterization of how P4 affects the chromatin and transcriptomic landscape during early human T_H1 differentiation, utilizing both ATAC-seq and RNA-seq. Time series analysis of the earlier events (0.5-24 hrs) during T_H1 differentiation revealed that P4 counteracted many of the changes induced during normal differentiation, mainly by downregulating key regulatory genes and their upstream transcription factors (TFs) involved in the initial T-cell activation. Members of the AP-1 co

SUBMITTER: Rundquist O 

PROVIDER: S-EPMC8848251 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature