DTL promotes melanoma progression through rewiring cell glucose metabolism.

ABSTRACT:

Background

To investigate the role of DTL in the development of skin cutaneous melanoma (SKCM) and possible mechanisms.

Methods

We examined the expression of DTL in SKCM in The Cancer Genome Atlas (TCGA) and Oncomine database and analyzed the relationship between DTL expression and melanoma prognosis. Furthermore, we silenced the DTL gene by RNA interference in A375 cells and investigated the effect of DTL silencing on the biological function of melanoma cells.

Results

The expression of DTL in SKCM was upregulated in the tumor tissues compared with the paired normal tissues. Survival analysis showed that higher DTL expression in SKCM patients was associated with poor clinical outcome compared with the lower DTL e

SUBMITTER: Lu JJ 

PROVIDER: S-EPMC8848355 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature