Autophagy related long non-coding RNA and breast cancer prognosis analysis and prognostic risk model establishment.

ABSTRACT:

Background

The role of autophagy-related long-stranded non-coding RNA (lncRNA) in breast cancer (BRCA) is unclear. We proposed to screen autophagy-related lncRNAs in BRCA and construct a prognostic risk assessment model to explore prognostic correlates.

Methods

We extracted BRCA lncRNAs from The Cancer Genome Atlas (TCGA) database and autophagy-related genes from the Human Autophagy Database (HADb), to screen for autophagy-related lncRNA pairs (ARLP) in BRCA. Single-factor Cox regression analysis and multi-factor Cox regression analysis were used to screen lncRNAs associated with BRCA prognosis, and risk models were established. We divided BRCA patients into high-risk and low-risk groups based on median risk scores. The single-sample gene set enrichment analysis (ssGSEA) alg

SUBMITTER: Luo Z 

PROVIDER: S-EPMC8848359 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature