Activation of the AKT/GSK-3β/β-catenin pathway via photobiomodulation therapy promotes neural stem cell proliferation in neonatal rat models of hypoxic-ischemic brain damage.

ABSTRACT:

Background

Hypoxic-ischemic brain damage (HIBD) significantly affects neurodevelopment in infants and is a leading cause of severe neurological morbidity and mortality in neonates. Our previous study found that photobiomodulation therapy (PBMT) improves the impaired spatial learning and memory of HIBD rat models. However, the neuroprotective mechanism conferred by PBMT in HIBD is unclear.

Methods

In the present study, HIBD model rats were treated with PBMT at 5 mW/cm² per day in the dark for 14 days (10 min each day), and primary neural stem cells (NSCs) after oxygen-glucose deprivation (OGD) were treated with PBMT for 10 min at 1, 5, 10, and 20 mW/cm² in the dark. PBMT promoted hippocampal neural stem cell (NSC) proliferation in vivo and in v

SUBMITTER: Liao Z 

PROVIDER: S-EPMC8848383 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature