Endothelial cells promote the proliferation and migration of Schwann cells.

ABSTRACT:

Background

After peripheral nerve injury, Schwann cells proliferate and migrate to the injured site, thereby promoting peripheral nerve regeneration. The process is regulated by various factors. Endothelial cells participate in the process via angiogenesis. However, the effects of endothelial cells on Schwann cells are not yet known. The present study sought to evaluate whether endothelial cells accelerate Schwann cell proliferation and migration.

Methods

We established a co-culture model of rat Schwann cells (RSC96s) and rat aortic endothelial cells (RAOECs), and studied the effects of endothelial cells on Schwann cells by evaluating changes in Schwann cell proliferation and migration and related multiple genes and their protein expressions in the co-culture model.

Resul

SUBMITTER: Meng DH 

PROVIDER: S-EPMC8848405 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature