CD73⁺ adipose-derived stem cells reduce scar formation through PLOD1.

ABSTRACT:

Background

Reducing cutaneous scar formation is important for assessing the success of skin wound healing. Although it is generally accepted that adipose-derived mesenchymal stem cells (AMSCs) have substantial therapeutic potential, efforts are continuously made to improve the outcome of AMSC therapy. Post-transcriptional suppression of procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) in AMSCs has been shown to greatly reduce scar formation during skin wound healing, likely through modulating macrophage polarization. In the present study, we tested whether a CD73⁺ subpopulation of AMSCs could reduce scar formation compared with CD73^- AMSCs.

Methods

The gene profile of CD73⁺ versus CD73^- AMSCs was obtained from a validat

SUBMITTER: Xu M 

PROVIDER: S-EPMC8848413 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature