Molecular mechanism and candidate biomarkers of morphine for analgesia and addiction effects.

ABSTRACT:

Background

Morphine and its substitutes are frequently used in the clinical treatment of acute severe pain and advanced cancer patients. Long-term irregular use of morphine will lead to severe dependence. However, the genes behind the analgesic and addictive effects of morphine still need to be revealed.

Methods

We retrieved and downloaded RNA expression data sets related to morphine pain and addiction effects from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes. Functional enrichment analysis was performed to analyze relevant pathways. Gene expression trends was used to screen key genes associated with addiction effects. miRNAs and PPIs were used to explore the functional mechanisms of genes.

Results

A total of 163 up-regulated a

SUBMITTER: Wang T 

PROVIDER: S-EPMC8848414 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature