Identification of a seven-gene prognostic signature using the gene expression profile of osteosarcoma.

ABSTRACT:

Background

Osteosarcoma is a malignant bone tumor that typically occurs in adolescents or children under 20 years of age. Developing efficient clinical prognostic markers is crucial for improving the treatment of osteosarcoma patients.

Methods

Three datasets related to osteosarcoma were acquired from the Gene Expression Omnibus (GEO) database. A gene signature model was established using the Limma package in the R software, univariate and multivariate survival analyses, and least absolute shrinkage and selection operator (LASSO) algorithms. The gene signature was then verified using external datasets.

Results

From the GEO database, 242 differentially expressed genes were identified. A total of 590 unique genes, including 380 genes from the human protein interaction ne

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8848427 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature