Regulatory mechanism of HIF-1α and its role in liver diseases: a narrative review.

ABSTRACT:

Objective

To summarize the structure, regulatory mechanism, and target genes of hypoxia-inducible factor-1 alpha (HIF-1α) and to comprehensively expound its role in various chronic liver diseases, thus providing a new perspective on the treatment of various liver diseases.

Background

Liver disease, especially chronic liver disease, is a long-standing public health problem; the mortality rate due to end-stage cirrhosis and liver cancer is high worldwide and continues to grow. Moreover, there is a lack of effective targeted therapy for most liver diseases, such as fatty liver, alcoholic liver disease (ALD), and advanced liver cancer, for which drug treatment approaches are extremely limited. As the liver is a highly aerobic organ, an insufficient oxygen supply can induce a ser

SUBMITTER: Chu Q 

PROVIDER: S-EPMC8848434 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature