Analysis of cancer-promoting genes related to chemotherapy resistance in esophageal squamous cell carcinoma.

ABSTRACT:

Background

According to histopathology, esophageal cancer can be divided into squamous cell carcinoma (SCC) and esophageal adenocarcinoma (adeno arcinoma). In China, 90% of esophageal cancer patients are squamous cell carcinoma. Cisplatin and fluaziridine are the main chemotherapy before and after surgery. Long-term drug treatment is often accompanied by the emergence of drug resistance of tumor cells. There are many mechanisms for the emergence of drug resistance of tumor cells, including the increase of drug efflux, the decrease of drug intake, the inhibition of cell apoptosis, and so on. This study aimed to investigate the key cancer-promoting genes related to chemotherapy resistance in esophageal squamous cell carcinoma (ESCC).

Methods

Two datasets from the Gene Expressi

SUBMITTER: Xie F 

PROVIDER: S-EPMC8848450 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature