Comparison of multi-omics results between patients with acute myeloid leukemia with long-term survival and healthy controls.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a group of highly heterogeneous diseases, for which approximately 35-40% of patients younger than 60 years old can be cured. However, the multi-omics characteristics and immune cell infiltration (ICI) status of adult long-term survival patients with AML patients compared with healthy controls are still relatively under-explored.

Methods

A total of 10 healthy transplant donors (control group) and 11 long-term survival patients with AML with de novo sampling from 2019 to 2020 at the Institute of Hematology in the Hospital of Blood Diseases were enrolled. We simultaneously performed 850 K methylation and bulk RNA-seq on these 21 patients for comparing the differential gene methylation and expression levels between the two groups

SUBMITTER: Song Y 

PROVIDER: S-EPMC8848452 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature